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Wednesday, December 6th, 2023

​9:00 - 10:00 - Opening Ceremony

​10:00 - 12:00 - Thematic Session: Drug Discovery

Chair: Dr. Carlos Alberto Manssour Fraga (Federal University of Rio de Janeiro, BR)

10:00 - 11:00 - Lecture 1 - LMW lead finding in drug discovery: from compound libraries to chemical starting points and beyond

Speaker: Dr. Daniel K. Baeschlin - (Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland)

Chair: Dra. Patrícia Machado Rodrigues e Silva Martins (Fiocruz, Rio de Janeiro, BR)

11:00- 12:00 - Lecture 2 - Eurofarma: A Journey through Innovation

Speaker: Dra. Júlia Monteiro (Head of Drug Discovery at Eurofarma, Brazil)

12:00 - 14:00 - Lunch

14:00 - 16:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry

Chair: Dr. Samuel dos Santos Valença (Federal University of Rio de Janeiro, BR)

14:00 - 15:00 - Lecture 3 - Pharmacological targeting of nanocompartments in COPD and Alzheimer

Speaker: Dra. Martina Schmidt (University of Groningen, Netherlands)

Chair: Dra. Luzineide W. Tinoco (Federal University of Rio de Janeiro, BR)

15:00 - 16:00 - Lecture 4 – Developing new pre-clinical candidates for Chagas disease.

Speaker: Dr. Manu De Rycker (University of Dundee, UK)

16:00 - 17:00 PPGFQM’ Best Thesis Diploma  Award

 

Chair: Dra. Lidia Moreira Lima (Federal University of Rio de Janeiro, BR)

 

16:00 - 16:30 - Lecture 1 - Development of multi-target compounds GPR40 agonists and HDAC6 inhibitors for the treatment of Alzheimer's disease.

Speaker: Dr. Pedro de Sena Murteira Pinheiro (PhD, awarded best thesis in 2021)

Chair: Dr. João Alfredo de Moraes Gomes da Silva (Federal University of Rio de Janeiro, BR)

 

16:30 - 17:00 - Lecture 2 - The LRA-DRC transition in aging: Establishing in vitro and in vivo models for determining novel molecular mechanisms and identifying pharmacological targets.

Speaker: Dra. Raquel Costa da Silva (PhD, awarded best thesis in 2022)

17:00 - 20:00 - Welcome cocktail and Chorinho show

Thursday, December 7th, 2023

9:00 - 10:00 - Chat with speakers (previously booked)

10:00 - 12:00 - Thematic Session: Drug Discovery 

Chair: Dr. Floriano Paes Silva Junior (Fiocruz, Rio de Janeiro, BR)

Lecture 5 - Artificial Intelligence in health: case studies in drug development

Speaker: Dra. Nuria E. Campillo (Spanish National Research Council (CSIC), Madrid, ES)

Chair: Dr. Newton Gonçalves de Castro (Federal University of Rio de Janeiro, BR)

Lecture 6 – Current Trends in Drug Discovery: What Can We Learn from Bibliometric Analysis?

Speaker: Dra. María José Dávila-Rodríguez (Life Sciences Solutions Consultant, Elsevier)

12:00 - 14:00 - Brunch, Poster Session and flash presentation (videos)

14:00 - 16:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry

 

Chair: Dra. Patrícia Dias Fernandes (Federal University of Rio de Janeiro, BR)

Lecture 7- Development and characterization of kinase sparing TPX2-tethering Aurora Kinase A ligands for the therapy of cancer

Speaker: Dr. Lars Zender (University Hospital Tübingen, Tübingen, Germany)

Chair: Dra. Mônica Macedo Bastos (Fiocruz, Rio de Janeiro, BR)

Lecture 8 - Optimizing Target Residence Time: Type 1.5 Inhibitors for p38a MAP Kinase

Application to treat Colorectal Cancer

Speaker: Dr. Stefan Laufer (Eberhard-Karls-Universität Tübingen, Tübingen, Germany)

 

16:00 - 17:30 - Oral Communication 

 

Chair: Dr. Leandro Miranda Alves (Federal University of Rio de Janeiro, BR)

1. Marissa El Hajje. Title: New Synthesized Chalcones in Cancer: Mechanism of Cell Death and Potency Identification

2. Lucas Silva Franco. Title: Investigation of biological activities of LASSBio Chemical Library to explore its pharmacological space

3. Carolinne Souza de Amorim. Title: Effect of extracellular vesicles derived from tumor-associated neutrophils on MDA-MB-231 cells

Chair: Dra. Manuella Lanzetti Daher de Deus

4. Juliana Fatima Vilachã Madeira Rodrigues dos Santos. Title: Exploring the mutational landscape of ROS1 mutations with a combination of in vitro and in silico techniques

5. Alexsandro Tavares Figueiredo Junior. Title: Potassium bixinate as a novel Nrf2/ARE activator drug-candidate: ROS scavenger and anti-inflammatory properties.

6. Philippe Vangrieken. Title: Dietary methylglyoxal improves insulin sensitivity and vascular function in high-fat diet-induced type 2 diabetic mice

17:30 - 18:00 - Chat with speakers (previously booked)

Friday, December 8th, 2023

9:00 - 10:00 - Chat with speakers (previously booked)

10:00 - 12:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry

Chair: Dra. Lucienne da Silva Lara Morcillo (Federal University of Rio de Janeiro, BR)

Lecture 9- Development of pharmacotherapy against accelerated vascular aging

Speaker: Dr. Anton Roks (Erasmus MC. Dept. of Internal Medicine, Vascular Aging Center, Erasmus University Rotterdam)

Chair: Dr. Arthur Eugen Kummerle (Federal Rural University of Rio de Janeiro, BR)

 

Lecture 10 – Macrocyclic Tetrapeptides – Versatile Compounds for Potential Drug Development.

Speaker: Dra. Jane V. Aldrich (Department of Medicinal Chemistry, College of Pharmacy, University of Florida, USA)

 

 

 

12:00 - 14:00 - Brunch, Poster Session and flash presentation (videos)

14:00 -16:00 - Oral Communication

 

Chair: Dra. Cláudia Lucia Martins da Silva (Federal University of Rio de Janeiro, BR)

 

1. Jordano Ferreira Reis. Title: Discovery of new piperine-based antischistosomal efflux pump inhibitors

2. Evelyn Santana Bezerra. Title: Capillary bioreactors based on nucleoside hydrolase from Leishmania donovani: a direct approach for ligand identification and characterization

3. Mayara Amorim Romanelli Ferreira dos Santos. Title: Wedelolactone reverts acute kidney injury resulting from Bothrops jararacussu envenomation

Chair: Dr. Luis Eduardo Menezes Quintas (Federal University of Rio de Janeiro, BR)

4. Soroush Mohammadi Jouabadi. Title: Chronic Colchicine Treatment Mitigates Vascular Stiffness by Enhancing Vascular Vasomotor Function: A Translational Study

5. Gabriela Morais de Oliveira Barros. Title: Effect of in vitro aging and its impact on bufalin response in epithelial renal cells

6. Thiago Moreira Pereira. Title: Design and synthesis of 1,2,4-triazoles: structural exploration in the inhibition of GSK-3β for the treatment of Alzheimer’s Disease

16:00 - 17:30 - Closing Lecture, Tribute to Professor François G. Noël and Closing Session

Chair: Dra. Lídia Moreira Lima (Federal University of Rio de Janeiro, BR)

 

Lecture 11- Kidney organoids for disease models and therapeutic development

Speaker: Dr. Ryuji Morizane (Massachusetts General Hospital and Harvard Medical School, Boston, USA)

 

20:00 - Dinner (entertainment)

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