4th
INTERNATIONAL SYMPOSIUM ON
PHARMACOLOGY AND MEDICINAL CHEMISTRY
December 6-8, 2023
​10:00 - 12:00 - Thematic Session: Drug Discovery
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Chair: Dr. Carlos Alberto Manssour Fraga (Federal University of Rio de Janeiro, BR)
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10:00 - 11:00 - Lecture 1 - LMW lead finding in drug discovery: from compound libraries to chemical starting points and beyond
Speaker: Dr. Daniel K. Baeschlin - (Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland)
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Chair: Dra. Patrícia Machado Rodrigues e Silva Martins (Fiocruz, Rio de Janeiro, BR)
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11:00- 12:00 - Lecture 2 - Eurofarma: A Journey through Innovation
Speaker: Dra. Júlia Monteiro (Head of Drug Discovery at Eurofarma, Brazil)
12:00 - 14:00 - Lunch
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14:00 - 16:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry
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Chair: Dr. Samuel dos Santos Valença (Federal University of Rio de Janeiro, BR)
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14:00 - 15:00 - Lecture 3 - Pharmacological targeting of nanocompartments in COPD and Alzheimer
Speaker: Dra. Martina Schmidt (University of Groningen, Netherlands)
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Chair: Dra. Luzineide W. Tinoco (Federal University of Rio de Janeiro, BR)
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15:00 - 16:00 - Lecture 4 – Developing new pre-clinical candidates for Chagas disease.
Speaker: Dr. Manu De Rycker (University of Dundee, UK)
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16:00 - 17:00 - PPGFQM’ Best Thesis Diploma Award
Chair: Dra. Lidia Moreira Lima (Federal University of Rio de Janeiro, BR)
16:00 - 16:30 - Lecture 1 - Development of multi-target compounds GPR40 agonists and HDAC6 inhibitors for the treatment of Alzheimer's disease.
Speaker: Dr. Pedro de Sena Murteira Pinheiro (PhD, awarded best thesis in 2021)
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Chair: Dr. João Alfredo de Moraes Gomes da Silva (Federal University of Rio de Janeiro, BR)
16:30 - 17:00 - Lecture 2 - The LRA-DRC transition in aging: Establishing in vitro and in vivo models for determining novel molecular mechanisms and identifying pharmacological targets.
Speaker: Dra. Raquel Costa da Silva (PhD, awarded best thesis in 2022)
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17:00 - 20:00 - Welcome cocktail and Chorinho show
Thursday, December 7th, 2023
9:00 - 10:00 - Chat with speakers (previously booked)
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10:00 - 12:00 - Thematic Session: Drug Discovery
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Chair: Dr. Floriano Paes Silva Junior (Fiocruz, Rio de Janeiro, BR)
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Lecture 5 - Artificial Intelligence in health: case studies in drug development
Speaker: Dra. Nuria E. Campillo (Spanish National Research Council (CSIC), Madrid, ES)
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Chair: Dr. Newton Gonçalves de Castro (Federal University of Rio de Janeiro, BR)
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Lecture 6 – Current Trends in Drug Discovery: What Can We Learn from Bibliometric Analysis?
Speaker: Dra. María José Dávila-Rodríguez (Life Sciences Solutions Consultant, Elsevier)
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12:00 - 14:00 - Brunch, Poster Session and flash presentation (videos)
14:00 - 16:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry
Chair: Dra. Patrícia Dias Fernandes (Federal University of Rio de Janeiro, BR)
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Lecture 7- Development and characterization of kinase sparing TPX2-tethering Aurora Kinase A ligands for the therapy of cancer
Speaker: Dr. Lars Zender (University Hospital Tübingen, Tübingen, Germany)
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Chair: Dra. Mônica Macedo Bastos (Fiocruz, Rio de Janeiro, BR)
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Lecture 8 - Optimizing Target Residence Time: Type 1.5 Inhibitors for p38a MAP Kinase
Application to treat Colorectal Cancer
Speaker: Dr. Stefan Laufer (Eberhard-Karls-Universität Tübingen, Tübingen, Germany)
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16:00 - 17:30 - Oral Communication
Chair: Dr. Leandro Miranda Alves (Federal University of Rio de Janeiro, BR)
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1. Marissa El Hajje. Title: New Synthesized Chalcones in Cancer: Mechanism of Cell Death and Potency Identification
2. Lucas Silva Franco. Title: Investigation of biological activities of LASSBio Chemical Library to explore its pharmacological space
3. Carolinne Souza de Amorim. Title: Effect of extracellular vesicles derived from tumor-associated neutrophils on MDA-MB-231 cells
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Chair: Dra. Manuella Lanzetti Daher de Deus
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4. Juliana Fatima Vilachã Madeira Rodrigues dos Santos. Title: Exploring the mutational landscape of ROS1 mutations with a combination of in vitro and in silico techniques
5. Alexsandro Tavares Figueiredo Junior. Title: Potassium bixinate as a novel Nrf2/ARE activator drug-candidate: ROS scavenger and anti-inflammatory properties.
6. Philippe Vangrieken. Title: Dietary methylglyoxal improves insulin sensitivity and vascular function in high-fat diet-induced type 2 diabetic mice
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17:30 - 18:00 - Chat with speakers (previously booked)
Friday, December 8th, 2023
9:00 - 10:00 - Chat with speakers (previously booked)
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10:00 - 12:00 - Thematic Session: Highlights in Pharmacology and Medicinal Chemistry
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Chair: Dra. Lucienne da Silva Lara Morcillo (Federal University of Rio de Janeiro, BR)
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Lecture 9- Development of pharmacotherapy against accelerated vascular aging
Speaker: Dr. Anton Roks (Erasmus MC. Dept. of Internal Medicine, Vascular Aging Center, Erasmus University Rotterdam)
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Chair: Dr. Arthur Eugen Kummerle (Federal Rural University of Rio de Janeiro, BR)
Lecture 10 – Macrocyclic Tetrapeptides – Versatile Compounds for Potential Drug Development.
Speaker: Dra. Jane V. Aldrich (Department of Medicinal Chemistry, College of Pharmacy, University of Florida, USA)
12:00 - 14:00 - Brunch, Poster Session and flash presentation (videos)
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14:00 -16:00 - Oral Communication
Chair: Dra. Cláudia Lucia Martins da Silva (Federal University of Rio de Janeiro, BR)
1. Jordano Ferreira Reis. Title: Discovery of new piperine-based antischistosomal efflux pump inhibitors
2. Evelyn Santana Bezerra. Title: Capillary bioreactors based on nucleoside hydrolase from Leishmania donovani: a direct approach for ligand identification and characterization
3. Mayara Amorim Romanelli Ferreira dos Santos. Title: Wedelolactone reverts acute kidney injury resulting from Bothrops jararacussu envenomation
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Chair: Dr. Luis Eduardo Menezes Quintas (Federal University of Rio de Janeiro, BR)
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4. Soroush Mohammadi Jouabadi. Title: Chronic Colchicine Treatment Mitigates Vascular Stiffness by Enhancing Vascular Vasomotor Function: A Translational Study
5. Gabriela Morais de Oliveira Barros. Title: Effect of in vitro aging and its impact on bufalin response in epithelial renal cells
6. Thiago Moreira Pereira. Title: Design and synthesis of 1,2,4-triazoles: structural exploration in the inhibition of GSK-3β for the treatment of Alzheimer’s Disease
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16:00 - 17:30 - Closing Lecture, Tribute to Professor François G. Noël and Closing Session
Chair: Dra. Lídia Moreira Lima (Federal University of Rio de Janeiro, BR)
Lecture 11- Kidney organoids for disease models and therapeutic development
Speaker: Dr. Ryuji Morizane (Massachusetts General Hospital and Harvard Medical School, Boston, USA)
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20:00 - Dinner (entertainment)